بررسی نتایج سیکل های ET-IVF در بیماران نازا با تخمدان های پلی کیستیک و بیماران با فاکتور لوله در موسسه رویان سال 79-77

Background and purpose : Infertility with an incidence of about 15% has mainly been one of the community burdens that have even been threatening to the continuity of the family life. One of the most prevalent causes of women infertility is ovarian causes particularly PCOS. The aim of this study was to determine the outcome of IVF & ET in women with PCOS in comparison with tubal factor. Materials and methods : This was a historical cohort study performed from 1997 to 1999, at Royan Institute. 33 patients with PCOS (without any other causes of infertility) who failed standard ovulation induction treatment with clomiphen citrate (≥6 cycles) underwent 33 cycles of IVF & ET. Controlled group include 76 patients with only tubal factor infertility. Long protocol with Buserelin (GnRHa)/HMG was used in this study. IVF & ET cycle characteristics were compared using students t-test and χ2 and Fisher’s exact test. Results : The results of this research showed that there were statistically significant difference in mean age and incidence of OHSS in two groups. Howerer there were no satistically significant differences in duration of follicular phase, the duration of GnRHa usage up to the onset of HMG, cyst number after using GnRHa, cyst aspiration percent, HMG ampoule retrieved oocyte, produced embryo per person, embryo transfer per person, cycle cancellation and pregnancy rate per embryo transfer in two groups. Conclusion : It seems that IVF & ET are successful procedures in PCOS patients resistant to other usual treatment and hormonal dysfunction of this group of patients did not affect the results.